Luisa Grillo graduated brilliantly in piano at the Bari Conservatory under the guidance of Giovanna Valente, and perfected her studies with undisputed piano maestros including Edit Picht-Axenfeld, Luigi Mostacci, Boris Petruciasky and Oxana Yablonskaya.
She has performed extensively in Italy (Trapani, Alcamo, Marsala, Palermo, Bari, Taranto, Barletta, Ostuni, Castellaneta, Bologna, etc.) both as soloist and in chamber orchestras, becoming a popular and artist with critics and the public.
She is soloist for a number of orchestras (Niccolò Piccinni Conservatory Orchestra - Bari, Antonio Scontrino Orchestra - Trapani, Mariele Ventre Orchestra - Bologna).
She studies organ, harpsichord and composition, and frequents several piano teaching courses (Donatella Bartolini, johannella Tafuri, Edith Picht-Axenfeld).
Since 1997 she has been President of the Minerbio section of the Friends of Music Association, Bologna, and directs all of its activities (J. Du Prè Music School, concerts, master classes, chamber music competitions, piano and singing).
Since 2001 she has been Artistic Director of the CITTÀ DI MINERBIO International Piano, Chamber Music and Singing Competition in Bologna; a competition patroned by local authorities which has established a strong reputation and met with great success due to the vast number and artistic quality of its participants.
She has been the principal piano professor at the J. Du Prè Music School since 1995, many of her students proving their high level of preparation by going on to win prestigious national and international competitions (more of 300 first price in piano competitions)
She to teach music in Italian public school from the 1999.
She is a frequent member of juries for piano competitions (Usti Nad Labem, Rospigliosi, Riviera Etrusca etc.), and collaborates in teaching activity exchanges with conservatories and music academies in Italy and abroad (Zagreb, Kazakhstan, Amsterdam etc).
From 2009 to 2012 he worked at the Frescobaldi conservatory in Ferrara and in 2010/2011 he collaborated with the Academy of Imola "Meetings with the master".
In 2021 she was proposed as candidate by the Mayor of Minerbio (Bo), Roberta Bonori, for the Tina Anselmi Award (5th edition), an award dedicated to women's work, promoted by the “Unione Donne” in Italia. The prize was awarded to her on the 8th of July in the courtyard of the Archiginnasio Library in Bologna.